Forward Miroslav Klose and midfielder Marco Reus are out of Euro 2012 qualifier against Germany, Austria and Azerbaijan next month due to injury.
Klose injured ribs 2-1 victory in a friendly against Uruguay on Sunday, while Reus was injured in the fall of Borussia Monchengladbach in the playoffs in the first leg against VfL Bochum and exacerbated the problem when he made the decisive goal of revenge.
And 'the third time is extracted a talented Reus, 21, who has yet to win his first cap, the Squad, and abandoned the lesion.
Klose knocks, open the door to Bayern Monaco, team-mate Mario Gomez will lead the attack after the top scorer in the Bundesliga has made the most of a rare start by opening goal of the network in Germany Uruguay.
The Klose 32 years came as a substitute in the second half, but not to make an impact.
"He took a painful rib injury. Medical tests on Monday revealed he has to refrain from training for the next few days, and therefore can not have at our disposal for the qualifiers", the German Football Federation said in a statement.
Germany, which on top of the European Championship qualifying group with five wins in as many matches, meet Austria on June 3 before taking on Azerbaijan four days later.
Klose, Germany's smaller second player behind Lothar Matthaeus, is chasing Gerd Müller all-time record score that netted 61 times 109 appearances.
Mueller scored 68 goals in 62 international matches.